Pickens County Vacations & Trips from $856

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Your Pickens County Vacation

Make planning your next big adventure quick and easy with a Pickens County vacation package. Whether it's the cuisine, nature or something else that draws you to this destination, our packages will help you experience it all. Start your trip to Pickens County with a couple of days in Clemson visiting popular sights like Memorial Stadium and South Carolina Botanical Gardens. Powdersville is another top city that lures travelers from near and far. Falls Park on the Reedy and Bon Secours Wellness Arena are two of the top places to see here. Expedia has hotels, flights, car rentals and more to help you create your own customized Pickens County vacation today.

Top destinations in Pickens County

The Latest Pickens County Vacation Packages

Price found within the past 48 hours. Click for updated prices.
The Windsor Boutique Hotel
Zoka - Modern Mountain Retreat
Pinners Compound- 4 BR hot tub fire pit
Family Bunk Cabin - Can't Bear To Leave
The Restoration Asheville

Find the Best Pickens County Vacation Packages

Pickens County Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Greenville-Spartanburg Intl. Airport (GSP)
Population
3,200
Top Sights
South Carolina Botanical Gardens, Keowee-Toxaway State Park and Larry W. Abernathy Waterfront Park

Pickens County Hotel Deals

Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center

2.5 out of 5
1310 Tiger Blvd Clemson SC
Fully refundableReserve now, pay when you stay
$110 nightly
The price is $122 total per night from May 17 to May 18
$122 total
May 17 - May 18
Total with taxes and fees
8.2/10 Very Good! (1,002 reviews)
Room was clean bed slept very good. Everyone that worked. There were very accommodating great location. This is my fourth time staying at this hotel.

Reviewed on May 14, 2026

Best Western Plus Clemson Hotel & Conference Center
The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson

4 out of 5
110 Sloan St Clemson SC
Fully refundableReserve now, pay when you stay
$189 nightly
The price is $210 total per night from May 17 to May 18
$210 total
May 17 - May 18
Total with taxes and fees
9.8/10 Exceptional! (797 reviews)
It’s the best small boutique hotel and the cleanest in all of Clemson. This is always my first choice if available.

Reviewed on May 5, 2026

The Shepherd Hotel Downtown Clemson
Inn @ Clemson

Inn @ Clemson

2.5 out of 5
1303 Tiger Blvd Clemson SC
Fully refundableReserve now, pay when you stay
$91 nightly
The price is $101 total per night from May 17 to May 18
$101 total
May 17 - May 18
Total with taxes and fees
8/10 Very Good! (1,014 reviews)
Inn at Clemson was very convenient to the University and close to where we needed to be. The staff was also great and very helpful. The accommodations were mediocre at best. We had 3 adult travelers and booked a double queen room . Typically in most hotels, a double queen would accommodate this size ...

Reviewed on May 14, 2026

Inn @ Clemson
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.